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Polycystin 2 Polyclonal Antibody, Biotin
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Product Details
BS-24450R-BIOTIN
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Polycystin 2
Conjugate
Biotin
Biotin
Biotin
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Polycystin-2 (PC2), encoded by the PKD2 gene, is a multi-pass membrane protein that functions as a nonselective calcium-permeable cation channel, primarily localized to the primary cilium and endoplasmic reticulum. It plays a key role in calcium signaling and mechanosensation, often forming a complex with polycystin-1 to regulate cellular responses to fluid flow. Mutations in PKD2 disrupt these processes and lead to autosomal dominant polycystic kidney disease (ADPKD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: autosomal dominant polycystic kidney disease type II; autosomal dominant polycystic kidney disease type II protein; PKD2; polycystic kidney disease 2 (autosomal dominant); transient receptor potential cation channel subfamily P member 2; unnamed protein product
Gene Aliases: APKD2; Pc-2; PC2; PKD4; TRPP2
UniProt ID: (Human) Q13563
Entrez Gene ID: (Human) 5311
receptor binding
voltage-gated ion channel activity
voltage-gated calcium channel activity
voltage-gated sodium channel activity
voltage-gated potassium channel activity
cation channel activity
calcium channel activity
potassium channel activity
sodium channel activity
calcium ion binding
protein binding
cytoskeletal protein binding
channel activity
outward rectifier potassium channel activity
voltage-gated cation channel activity
identical protein binding
protein homodimerization activity
actinin binding
HLH domain binding
ion channel binding
calcium-induced calcium release activity
ATPase binding
phosphoprotein binding
transcription regulator inhibitor activity
branching involved in ureteric bud morphogenesis
kidney development
liver development
embryonic placenta development
heart looping
detection of nodal flow
potassium ion transport
sodium ion transport
calcium ion transport
cell surface receptor signaling pathway
JAK-STAT cascade
determination of left/right symmetry
heart development
negative regulation of cell proliferation
positive regulation of gene expression
Wnt signaling pathway
calcium-mediated signaling
spinal cord development
neural tube development
cellular response to reactive oxygen species
metanephric part of ureteric bud development
sodium ion transmembrane transport
aorta development
regulation of cell proliferation
chordate embryonic development
cilium organization
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
detection of mechanical stimulus
release of sequestered calcium ion into cytosol
protein tetramerization
protein homotetramerization
protein heterotetramerization
centrosome duplication
regulation of cell cycle
transmembrane transport
placenta blood vessel development
renal tubule morphogenesis
renal artery morphogenesis
calcium ion transmembrane transport
cellular response to calcium ion
cellular response to cAMP
cellular response to hydrostatic pressure
cellular response to osmotic stress
cellular response to fluid shear stress
potassium ion transmembrane transport
determination of liver left/right asymmetry
metanephric mesenchyme development
mesonephric tubule development
mesonephric duct development
metanephric smooth muscle tissue development
metanephric cortex development
metanephric ascending thin limb development
metanephric cortical collecting duct development
metanephric distal tubule development
metanephric S-shaped body morphogenesis
regulation of calcium ion import
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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