Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC constitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity.
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Protein Aliases: hVDAC1; MGC111064; Mitochondrial outer membrane protein porin 1; Mitochondrial Porin; porin POR1; PORIN-31-HL; VD; VDAC-1; Voltage-dependent anion-selective channel protein 1
Gene Aliases: N2441; OMP2; POR1; VDAC1; YNL055C; YNL2441C
UniProt ID: (Baker's yeast) P04840
Entrez Gene ID: (Baker's yeast) 855669