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|Tested species reactivity||Yeast|
|Published species reactivity||Yeast, Fungi, Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||VDAC-1 from S. cerevisiae, denatured in SDS-PAGE|
|Storage buffer||HEPES buffered saline|
|Contains||0.02% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1.0 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Porin belongs to the eukaryotic mitochondrial porin family of voltage dependent anion channels which allow the transport of adenine nucleotides and other metabolites throught the outer mitochondrial membrane. The conformation of the protein is regulated by membrane potential, which affects its divalent metal ion selectivity. Porin is also involved in mitochondrial apoptosis, forming permeability transition pore complexes (PTPC) in association with adenine nucleotide transporter, and cyclophilin D, leading to release of apoptogenic factors that activate caspases and initiate cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Investigating interference with apoptosis induction by bacterial proteins.
459500 was used in immunocytochemistry to describe a method to study the anti-apoptotic effect of Ats-1.
|Niu H,Rikihisa Y||Methods in molecular biology (Clifton, N.J.) (1197:169)||2014|
Crosstalk between mitochondrial stress signals regulates yeast chronological lifespan.
459500 was used in western blot to test the requirement for mtDNA in the adaptive mtROS longevity signal.
|Schroeder EA,Shadel GS||Mechanisms of ageing and development (135:41)||2014|
The role of snx41-based pexophagy in magnaporthe development.
459500 was used in western blot to study the role of pexophagy in the fungal pathogenic life cycle.
|Deng Y,Qu Z,Naqvi NI||PloS one (8:null)||2013|
Repression of mitochondrial translation, respiration and a metabolic cycle-regulated gene, SLF1, by the yeast Pumilio-family protein Puf3p.
459500 was used in western blot to study the coordination of gene expression between the nuclear and mitochondrial genomes.
|Chatenay-Lapointe M,Shadel GS||PloS one (6:null)||2011|
N2441; OMP2; POR1; VDAC1; YNL2441C