|Tested species reactivity||Human|
|Published species reactivity||Artificial Control, Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fusion protein containing amino acids 1-79 of human presenilin-1.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Early to intermediate steps of tumor embolic formation involve specific proteolytic processing of E-cadherin regulated by Rab7.
71-1300 was used in western blot to study lymphovascular embolus.
|Ye Y,Gao JX,Tian H,Yearsley K,Lange AR,Robertson FM,Barsky SH||Molecular cancer research : MCR (10:713)||2012|
||Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide.||Maltese WA,Wilson S,Tan Y,Suomensaari S,Sinha S,Barbour R,McConlogue L||The Journal of biological chemistry (276:20267)||2001|
|Artificial Control||Not Cited||Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide.||Maltese WA,Wilson S,Tan Y,Suomensaari S,Sinha S,Barbour R,McConlogue L||The Journal of biological chemistry (276:20267)||2001|