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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 224 of Human PRP|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-27313 targets PRP in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-27313 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 224 of Human PRP.
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CD230; CD230 antigen; CJD; GSS; major prion protein; MGC26679; prion-related protein; PRIP; PRNP; PrPc
AA960666; AI325101; ALTPRP; ASCR; CD230; CJD; GSS; KURU; p27-30; PRIP; Prn-i; Prn-p; PRNP; PRP; PrP27-30; PrP33-35C; PrP<C>; PrPC; PrPSc; Sinc