MA1-20292 detects procalcitonin in human samples.
MA1-20292 has been successfully used in ELISA and Western blot procedures.
The MA1-20292 immunogen is a recombinant fragment of human procalcitonin.
Procalcitonin (PCT) is a 116 amino acid residue peptide with molecular weight of ~ 13 kDa. It belongs to a group of related proteins including calcitonin gene-related peptides I and II, amylin, adrenomodulin and calcitonin (CAPA peptide family). PCT, like other peptides of CAPA family, appears from the common precursor pre-procalcitonin consisting of 141 amino acids by removal of 25 a.a.r. from N-terminus. PCT is produced normally in C-cells of the thyroid glands. It undergoes successive cleavages to form three molecules: N-terminal fragment (55 a.a.r.), calcitonin (32 a.a.r.) and katacalcin (21 a.a.r.). It has been shown that the level of PCT is considered to be one of the earliest and most specific markers of sepsis. However, several studies revealed that elevated PCT level in human blood could be detected not only in cases of sepsis and infection, but also in cases of surgery, polytrauma, heat shock and cardiogenic shock (Meisner M. and Reinhart K.). The importance of PCT measurements in combination with cTnT or cTnl during heart transplation to predict an early graft failure has been proved (Potapov EV., et al).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha-type CGRP; Calcitonin; calcitonin 1; Calcitonin carboxyl-terminal peptide; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin-related polypeptide alpha; calcitonin/calcitonin-related polypeptide, alpha; CCP; CGRP-I; Katacalcin; PDN-21
Gene Aliases: CALC1; CALCA; CGRP; CGRP-I; CGRP1; CT; KC; PCT
UniProt ID: (Human) P06881
Entrez Gene ID: (Human) 796