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Biologo
Procollagen Type III, human, bovine Polyclonal Antibody
Product Details
CO23311-01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Procollagen type III deprived of the C-terminal PIIICP peptide
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: Human or bovine skin and liver.
Reactivity: Human and other primates (no reactivity in chicken, cat, rabbit, rat, sheep and goat).
Target Information
Collagen type III is synthesized as a homo-trimeric pro-collagen (Procollagen III) comprising three identical pro-alpha(III)-chains. It has been reported that procollagen type III is processed extracellularly at the ECM and can be found by immunostaining intracellular as well as extracellular. Collagens consist of a family of highly specialized glycoproteins of which at least 16 genetically distinct types are known to date. The basal unit of a collagen molecule consists of a triple-helical structure formed by 3 alpha-chains. Predominant amino acids are glycine, proline and hydroxproline. Regularly also lysines and hydroxylysines occur, which are responsible for cross-linkage and glycosylation of the protein chains. Different composition of alpha-chains and different glycosylation contribute to the high variability of collagens in different tissues and organs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha1 (III) collagen; Collagen alpha-1(III) chain; collagen, fetal; collagen, type III, alpha 1; collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant); collagen, type III, alpha 1 chain, fibril forming; Ehlers-Danlos syndrome type IV, autosomal dominant
Gene Aliases: COL3A1; EDS4A
UniProt ID: (Human) P02461
Entrez Gene ID: (Bovine) 510833, (Human) 1281
cerebral cortex development
positive regulation of Rho protein signal transduction
negative regulation of neuron migration
skeletal system development
cell-matrix adhesion
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
heart development
aging
response to radiation
response to mechanical stimulus
peptide cross-linking
platelet activation
extracellular matrix organization
collagen fibril organization
collagen catabolic process
response to cytokine
wound healing
extracellular fibril organization
skin development
digestive tract development
regulation of immune response
negative regulation of immune response
aorta smooth muscle tissue morphogenesis
cellular response to amino acid stimulus
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