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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||The region encoding amino acids 1-101 of the human progesterone receptor expressed in E. coli.|
|Storage buffer||PBS, pH 7.4|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-23268 detects Progesterone receptor in Human samples.
MA1-23268 has been successfully used in Western Blot procedures. A suggested positive control for this product is MCF7.
MA1-23268 immunogen corresponds to the region encoding amino acids 1-101 of the human progesterone receptor expressed in E. coli..
Store at 4°C short term. For extednded storage aliquot and store at -20°C or below, avoiding freeze/thaw cycles.
The human Progesterone Receptor (PgR) is a member of the steroid family of nuclear receptors. PgR is found as a 120 kDa protein (Form B) or a 94 kDa protein (Form A) due to the use of alternative translation initiation sites. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
NR3C3; nuclear receptor subfamily 3 group C member 3; PGR
NR3C3; PGR; PR