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|Tested species reactivity||Bovine, Chicken, Human, Rabbit|
|Published species reactivity||Mouse, Human, Chicken|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Partially purified PgR from a human endometrial carcinoma (EnCa 101) grown in athymic mice|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay Dependent|
|Immunoprecipitation (IP)||2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-12653 targets Progesterone Receptor in IF and IP applications and shows reactivity with Bovine, Chicken, Human, and Rabbit samples.
The MA5-12653 immunogen is partially purified PgR from a human endometrial carcinoma (EnCa 101) grown in athymic mice.
Human PgR exists in two forms: 116kDa (B-form) and 81kDa (A-form). It acts as ligand activated transcription factor to regulate expression of the target genes. Null mutation in PgR gene leads to pleiotrophic reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Hypermethylation of the progesterone receptor A in constitutive antiprogestin-resistant mouse mammary carcinomas.
MA5-12653 was used in immunohistochemistry and western blot to study the role of hypermethylation of the progesterone receptor A in constitutive antiprogestin-resistant mouse mammary carcinomas
|Wargon V,Fernandez SV,Goin M,Giulianelli S,Russo J,Lanari C||Breast cancer research and treatment (126:319)||2011|
Tip30 deletion in MMTV-Neu mice leads to enhanced EGFR signaling and development of estrogen receptor-positive and progesterone receptor-negative mammary tumors.
MA5-12653 was used in immunohistochemistry to study the mechanism by which Tip30 loss leads to development of mammary tumors
|Zhang C,Mori M,Gao S,Li A,Hoshino I,Aupperlee MD,Haslam SZ,Xiao H||Cancer research (70:10224)||2010|
Inflammatory status influences aromatase and steroid receptor expression in endometriosis.
MA5-12653 was used in immunohistochemistry to study the effect of inflammatory status on aromatase and steroid receptor expression in endometriosis
|Bukulmez O,Hardy DB,Carr BR,Word RA,Mendelson CR||Endocrinology (149:1190)||2008|
Effect of tamoxifen on endometrial histology, hormone receptors, and cervical cytology: a prospective study with follow-up.
MA5-12653 was used in immunohistochemistry to study the effect of tamoxifen on endometrial histology and gene expression
|Leslie KK,Walter SA,Torkko K,Stephens JK,Thompson C,Singh M||Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry (15:284)||2007|
Relationship of estrogen and progesterone receptors to clinical outcome in metastatic endometrial carcinoma: a Gynecologic Oncology Group Study.
MA5-12653 was used in immunohistochemistry to investigate the role of estrogen and progesterone receptors in the metastatic endometrial carcinoma
|Singh M,Zaino RJ,Filiaci VJ,Leslie KK||Gynecologic oncology (106:325)||2007|
Progesterone receptor isoform (A/B) ratio of human fetal membranes increases during term parturition.
MA5-12653 was used in immunohistochemistry to study changes in the progesterone receptor isoform (A/B) ratio of human fetal membranes during term parturition
|Oh SY,Kim CJ,Park I,Romero R,Sohn YK,Moon KC,Yoon BH||American journal of obstetrics and gynecology (193:1156)||2005|
Progesterone receptor isoform identification and subcellular localization in endometrial cancer.
MA5-12653 was used in immunohistochemistry, immunoprecipitation, and western blot to study the subcellular localization of progesterone receptor isoforms A and B in endometrial cancer
|Leslie KK,Stein MP,Kumar NS,Dai D,Stephens J,Wandinger-Ness A,Glueck DH||Gynecologic oncology (96:32)||2005|
Changes in the presence of progesterone receptor isoforms in the oviduct magnum of newly-hatched chicks after gonadotropins treatment.
MA5-12653 was used in immunohistochemistry to study the effect of gonadotropins on progesterone receptor isoforms in the oviduct magnum of newly-hatched chicks
|González-Morán G,Camacho-Arroyo I||Life sciences (73:871)||2003|
Progesterone receptor isoforms in ovary of newly-hatched chick after gonadotropin treatment during embryonic development.
MA5-12653 was used in immunohistochemistry to study the effect of embryonic gonadotropin treatment on progesterone receptor isoforms in newly-hatched chick ovary
|González-Morán G,García-Izquierdo J,Camacho-Arroyo I||Comparative biochemistry and physiology. Part A, Molecular & integrative physiology (132:519)||2002|
Progesterone receptor isoforms expression pattern in human astrocytomas.
MA5-12653 was used in immunohistochemistry to study the expression of different progesterone receptor isoforms in human astrocytomas
|González-Agüero G,Ondarza R,Gamboa-Domínguez A,Cerbón MA,Camacho-Arroyo I||Brain research bulletin (56:43)||2001|
Reversal of antiprogestin resistance and progesterone receptor isoform ratio in acquired resistant mammary carcinomas.
MA5-12653 was used in western blot to study antiprogestin resistance and the progesterone receptor isoform ratio in acquired resistant mammary carcinomas
|Wargon V,Helguero LA,Bolado J,Rojas P,Novaro V,Molinolo A,Lanari C||Breast cancer research and treatment (116:449)||2009|
Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells.
MA5-12653 was used in immunocytochemistry to study the role of KLF9 in regulating estrogen receptor-alpha signaling in endometrial adenocarcinoma cells
|Velarde MC,Zeng Z,McQuown JR,Simmen FA,Simmen RC||Molecular endocrinology (Baltimore, Md.) (21:2988)||2007|
nuclear receptor subfamily 3 group C member 3; PR; progesterone receptor
NR3C3; PGR; PR