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|Tested species reactivity||Human|
|Published species reactivity||Mouse, Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues surrounding pSer115 of human progesterone receptor|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Contains||<0.02% sodium azide|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:200|
|Immunohistochemistry (Paraffin) (IHC (P))||1:800|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other PR family members.
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Tissue expression of steroid hormone receptors is associated with differential immune responsiveness.
MA5-14842 was used in flow cytometry to investigate the expressionof steroid hormone receptors in leukocytes from lymphoid and non-lymphoid tissues
|Butts CL,Jones YL,Lim JK,Salter CE,Belyavskaya E,Sternberg EM||Brain, behavior, and immunity (25:1000)||2011|
TNF superfamily gene polymorphism as prognostic factor in early breast cancer.
MA5-14842 was used in immunohistochemistry to identify the effects of polymorphisms in apoptosis-related genes on breast cancer survival
|Jung JH,Chae YS,Moon JH,Kang BW,Kim JG,Sohn SK,Park JY,Lee MH,Park HY||Journal of cancer research and clinical oncology (136:685)||2010|
Epidermal growth factor receptor signaling enhanced by long-term medroxyprogesterone acetate treatment in endometrial carcinoma.
MA5-14842 was used in immunocytochemistry to investigate the effect of long-term medroxyprogesterone acetate treatment on progesterone receptor expression in ishikawa endometrial carcinoma cells
|Zhao S,Chen X,Lu X,Yu Y,Feng Y||Gynecologic oncology (105:45)||2007|
Nuclear receptor subfamily 3 group C member 3; PR; Progesterone receptor
NR3C3; PGR; PR