|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Semi-purified human prolactin receptor|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-11955 targets Prolactin Receptor in IHC (P) applications and shows reactivity with Human samples.
The MA5-11955 immunogen is semi-purified human prolactin receptor.
Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor) which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Pineal Diffuse Large B-Cell Lymphoma Concomitant With Pituitary Prolactinoma: Possible Correlation Between 2 Distinguished Pathologies: A Case Report.
MA5-11955 was used in immunohistochemistry and western blot to analyze a case report involving pineal diffuse large B-cell lymphoma concomitant with pituitary prolactinoma and a possible correlation between two pathologies
|Kim YJ,Kim HK,Yang DH,Jung S,Noh MG,Lee JH,Lee KH,Moon KS||Medicine (95:null)||2016|
Amplification of the prolactin receptor gene in mammary lobular neoplasia.
MA5-11955 was used in immunohistochemistry to study amplification of the prolactin receptor gene in mammary neoplasia.
|Tran-Thanh D,Arneson NC,Pintilie M,Deliallisi A,Warren KS,Bane A,Done SJ||Breast cancer research and treatment (128:31)||2011|
Reversed Expression of the JAK/STAT Pathway Related Proteins Prolactin Receptor and STAT5a in Normal and Abnormal Breast Epithelial Cells.
MA5-11955 was used in immunohistochemistry to investigate PRLR and STAT5a expression in breast tissues
|Bratthauer GL,Strauss BL,Barner R||Breast cancer : basic and clinical research (1:7)||2011|
Prolactin receptor expression in gynaecomastia and male breast carcinoma.
MA5-11955 was used in immunohistochemistry to study differential prolactin receptor expression in gynaecomastia and male breast carcinoma
|Ferreira M,Mesquita M,Quaresma M,André S||Histopathology (53:56)||2008|
Expression of prolactin receptor and prolactin in normal and malignant thyroid: a tissue microarray study.
MA5-11955 was used in immunohistochemistry to study the expression of prolactin receptor and prolactin in normal and malignant thyroid using tissue microarrays
|Costa P,Catarino AL,Silva F,Sobrinho LG,Bugalho MJ||Endocrine pathology (17:377)||2007|
Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity.
MA5-11955 was used in immunocytochemistry to study the role of prolactin receptor antagonism in doxorubicin and paclitaxel cytoxicity
|Howell SJ,Anderson E,Hunter T,Farnie G,Clarke RB||Breast cancer research : BCR (10:null)||2008|