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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Semi-purified human prolactin receptor|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-11955 targets Prolactin Receptor in IHC (P) applications and shows reactivity with Human samples.
The MA5-11955 immunogen is semi-purified human prolactin receptor.
Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor) which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Amplification of the prolactin receptor gene in mammary lobular neoplasia.
MA5-11955 was used in immunohistochemistry to study amplification of the prolactin receptor gene in mammary neoplasia.
|Tran-Thanh D,Arneson NC,Pintilie M,Deliallisi A,Warren KS,Bane A,Done SJ||Breast cancer research and treatment (128:31)||2011|
Reversed Expression of the JAK/STAT Pathway Related Proteins Prolactin Receptor and STAT5a in Normal and Abnormal Breast Epithelial Cells.
MA5-11955 was used in immunohistochemistry to investigate PRLR and STAT5a expression in breast tissues
|Bratthauer GL,Strauss BL,Barner R||Breast cancer : basic and clinical research (1:7)||2011|
Prolactin receptor expression in gynaecomastia and male breast carcinoma.
MA5-11955 was used in immunohistochemistry to study differential prolactin receptor expression in gynaecomastia and male breast carcinoma
|Ferreira M,Mesquita M,Quaresma M,André S||Histopathology (53:56)||2008|
Expression of prolactin receptor and prolactin in normal and malignant thyroid: a tissue microarray study.
MA5-11955 was used in immunohistochemistry to study the expression of prolactin receptor and prolactin in normal and malignant thyroid using tissue microarrays
|Costa P,Catarino AL,Silva F,Sobrinho LG,Bugalho MJ||Endocrine pathology (17:377)||2007|
Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity.
MA5-11955 was used in immunocytochemistry to study the role of prolactin receptor antagonism in doxorubicin and paclitaxel cytoxicity
|Howell SJ,Anderson E,Hunter T,Farnie G,Clarke RB||Breast cancer research : BCR (10:null)||2008|
delta 4-delta 7/11 truncated prolactin receptor; delta 4-SF1b truncated prolactin receptor; hPRL receptor; prolactin receptor delta 7/11; secreted prolactin binding protein
HPRL; hPRLrI; MFAB; PRLR