MA5-11955 targets Prolactin Receptor in IHC (P) applications and shows reactivity with Human samples.
The MA5-11955 immunogen is semi-purified human prolactin receptor.
Prolactin (PRL) is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor (PRLR), a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. PRLR consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.
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Protein Aliases: delta 4-delta 7/11 truncated prolactin receptor; delta 4-SF1b truncated prolactin receptor; hPRL receptor; PRL-R; Prolactin receptor; prolactin receptor delta 7/11; secreted prolactin binding protein
Gene Aliases: HPRL; hPRLrI; MFAB; PRLR
UniProt ID: (Human) P16471
Entrez Gene ID: (Human) 5618