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|Tested species reactivity||Bovine, Human|
|Published species reactivity||Mouse, Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Cellular Proteosome fraction containing multiple á subunits, prepared from bovine cells.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||1.0-5 ug/ml|
|Immunoprecipitation (IP)||5-10 ug|
|Western Blot (WB)||1-5 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Mouse||Not Cited||Carbohydrates act as sorting determinants in ER-associated degradation of tyrosinase.||Svedine S,Wang T,Halaban R,Hebert DN||Journal of cell science (117:2937)||2004|
Parkinson's disease transgenic mitochondrial cybrids generate Lewy inclusion bodies.
32-1100 was used in immunocytochemistry to report the generation of fibrillar and vesicular inclusions in a long-term cybrid cell culture model used to study Parkinson's disease.
|Trimmer PA,Borland MK,Keeney PM,Bennett JP,Parker WD||Journal of neurochemistry (88:800)||2004|
proteasome (prosome, macropain) subunit, alpha type, 8; proteasome subunit alpha type 7-like protein variant 1; Proteasome subunit alpha type-7-like; PSMA7L