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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 264 of Human Proteasome beta 4|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-27521 targets Proteasome beta 4 in WB applications and shows reactivity with Human samples.
The PA5-27521 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 264 of Human Proteasome beta 4.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
26 kDa prosomal protein; 4; beta type; HsBPROS26; HsN3; Macropain beta chain; Multicatalytic endopeptidase complex beta chain; PROS-26; PROS26; proteasome (prosome, macropain) subunit, beta type, 4; Proteasome beta chain; Proteasome chain 3; proteasome subunit; Proteasome subunit beta type-4; proteasome subunit HsN3; proteasome subunit, beta type, 4; testis tissue sperm-binding protein Li 79P
HN3; HsN3; PROS-26; PROS26; PSMB4