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Invitrogen
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:5,000 | - |
ELISA (ELISA) |
Assay-dependent | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Zebrafish |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant Zebrafish Protein tyrosine phosphatase, receptor type, s, a protein (269-424AA) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
3.12 mg/mL |
Purification |
Protein G |
Storage buffer |
PBS, pH 7.4, with 50% glycerol |
Contains |
0.03% ProClin 300 |
Storage conditions |
-20°C or -80°C if preferred |
RRID |
AB_2867602 |
PRL-3 is a newly identified metastasis-related gene, which codes a 22 KDa non-classical protein tyrosine phosphatase with a C-terminal prenylation motif. It is located at the cytoplasmic membrane when prenylated and in the nucleus when nonpreylated. PRL-3 has at least 75% amino-acid sequence similarity with PRL-1 and PRL-2, the other two members of the PRL family. Recently, Zeng and colleagues found that Chinese hamster ovary cells stably expressing PRL-3 exhibited enhanced motility, invasive activity, and induced metastatic tumor formation in nude mice. And in clinical study, PRL-3 is consistently overexpressed in liver metastasis in colorectal cancer cells. These findings suggest PRL-3 is a new target for the early diagnosis of metastasis as well as the drug discovery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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