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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.|
|Storage buffer||PBS with 50% glycerol|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15540 targets Proteinase 3 in WB applications and shows reactivity with Human samples.
The MA5-15540 immunogen is purified recombinant fragment of human Proteinase 3 expressed in E. Coli.
MA5-15540 detects Proteinase 3 which has a predicted molecular weight of approximately 28kDa.
Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ACPA; azurophil granule protein 7; C-ANCA; C-ANCA antigen; CANCA; leukocyte proteinase 3; MBN; MBT; neutrophil proteinase 4; NP4; PR-3; PR3; PRTN3; serine proteinase, neutrophil; wegener autoantigen; Wegener granulomatosis autoantigen
ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3; PRTN3