The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Rat, Zebrafish, X. laevis, Chicken, Bovine, Dog, Horse, Pig and Cat
This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. Sacsin has been found to protect against mutant ataxin-1. A pseudogene associated with this gene is located on chromosome 11. Alternative splicing of this gene results in multiple transcript variants.
Protein Aliases: DKFZp586I0923; homolog of mouse quaking QKI (KH domain RNA binding protein); Hqk; lethal, Chr 17, U Wisconsin 1; MqkI; Protein quaking; QKI, KH domain containing, RNA binding; QKI-5 protein; quaking homolog, KH domain RNA binding; RNA Binding (QKI); RNA binding protein HQK
Gene Aliases: 1110003F05Rik; 1500005P18; HKQ; Hqk; hqkI; l(17)-1Wis; l17Wis1; QK; QK1; QK3; Qka1; QKI
Molecular Function: RNA splicing factor