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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG|
|Immunogen||Amino terminal fragment of human Rad1 purified from E. coli.|
|Storage buffer||PBS/0.2M tris glycine, pH 7, with 1mM EGTA, 50% glycerol|
|Contains||0.025% ProClin 300|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-23350 detects Rad1 in Human samples.
MA1-23350 has been successfully used in Western Blot procedures.
MA1-23350 immunogen corresponds to Amino terminal fragment of human Rad1 purified from E. coli..
Human Rad1 is a component of a heterotrimeric PCNA-like complex that also contains the Rad9 and Hus1 proteins. This complex is believed to be involved in cellular responses to DNA damage, possibly by associating with Rad17 and several components of the PCNA-loading heteropentamer, replication factor C. Human Rad1 exhibits significant homology to Rad1 from S. pombe, and its expression in yeast rad1 mutants has been shown to partially restore radiation resistance and G2-checkpoint activity. It has also been shown to possess exonuclease activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
cell cycle checkpoint protein Hrad1; checkpoint control protein HRAD1; DNA repair exonuclease rad1 homolog; DNA repair exonuclease REC1; exonuclease homolog RAD1; HRAD1; RAD1 checkpoint clamp component; RAD1 homolog; rad1-like DNA damage checkpoint protein; REC1
HRAD1; RAD1; REC1