|Immunocytochemistry (ICC)||2-3 µg/ml|
|Immunofluorescence (IF)||2-3 µg/ml|
|Immunoprecipitation (IP)||2 µg|
|Western Blot (WB)||1-2 µg/ml|
|Tested Species reactivity||Human, Non-human primate|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Full length human recombinant protein of human RALBP1 (NP_006779) produced in HEK293T cell.|
|Storage buffer||PBS with 1mg/ml BSA, 30% glycerol|
|Contains||0.05% sodium azide|
MA1-035 detects RALBP1 in human and monkey samples and has been successfully used in Western blotting and immunoprecipitation applications.
Can specifically activate hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDC2 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 76 kDa Ral-interacting protein; Dinitrophenyl S-glutathione ATPase; DNP-SG ATPase; Ral-interacting protein 1; RalA-binding protein 1; RalBP1; RIP1; RLIP1; RLIP76
Gene Aliases: RALBP1; RIP1; RLIP1; RLIP76
UniProt ID: (Human) Q15311
Entrez Gene ID: (Human) 10928
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