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|Tested species reactivity||Bovine, Hamster, Human, Mouse, Clawed frog|
|Published species reactivity||Mouse|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Denatured, recombinant, human ran protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay dependent|
|Immunocytochemistry (ICC)||Assay dependent|
|Immunoprecipitation (IP)||Assay dependent|
|Western Blot (WB)||0.5-1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunocytochemistry (ICC)||See 1 publications below|
MA1-20581 detects ran in human, mouse, xenopus laevis, bovine, and hamster samples.
MA1-20581 has been successfully used in ELISA, immunocytochemistry, immunoprecipitation, and Western blot procedures.
The MA1-20581 immunogen is denatured, recombinant, human ran protein.
Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.
MA1-20581 was used in immunocytochemistry to investigate the neuroprotective effect of RANBP2 insufficiency against light damage
|Cho KI,Yi H,Tserentsoodol N,Searle K,Ferreira PA||Disease models & mechanisms (3:595)||2010|
androgen receptor-associated protein 24; ARA24; Gsp1; GTP-binding nuclear protein Ran; GTPase Ran; guanosine triphosphatase Ran; member RAS oncogene family; OK/SW-cl.81; ran GTP-binding protein; RAN, member RAS oncogene family; RanGTPase; ras-like protein TC4; ras-related nuclear protein; TC4
ARA24; Gsp1; OK/SW-cl.81; RAN; ran-1; TC4; xran