|Immunohistochemistry (IHC)||3-5 ug/ml|
|Western Blot (WB)||0.05-0.1 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide corresponding to the C terminus amino acids LSVKEETKEDAEEKQ.|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HpaII tiny fragments locus 9A; RAN binding protein 1; Ran-binding protein 1; Ran-specific GTPase-activating protein; RanBP1; testis secretory sperm-binding protein Li 221n
Gene Aliases: HTF9A; RANBP1
UniProt ID: (Human) P43487
Entrez Gene ID: (Human) 5902
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