|Tested species reactivity||Mouse|
|Published species reactivity||Human|
|Host / Isotype||Rat / IgG2a|
|Immunogen||Recombinant, full length mouse protein, expressed in E. coli.|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Inhibition Assays (IA)||Assay Dependent|
|Immunocytochemistry (ICC)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|ELISA (ELISA)||See 1 publications below|
MA1-24665 has been successfully used in ICC/IF and inhibition procedures.
The MA1-24665 immunogen is recombinant, full length mouse protein, expressed in E. coli.
This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Human mast cell activation with virus-associated stimuli leads to the selective chemotaxis of natural killer cells by a CXCL8-dependent mechanism.
MA1-24665 was used in ELISA to study the role of human mast cells in the recruitment of natural killer cells
|Burke SM,Issekutz TB,Mohan K,Lee PW,Shmulevitz M,Marshall JS||Blood (111:5467)||2008|