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Product Details
CF810381
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI3G1
Immunogen
Human recombinant protein fragment corresponding to amino acids 1-223 of human RARG produced in E.coli.
Conjugate
Unconjugated
Form
lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Retinoic acid, a metabolite of vitamin A, is necessary for normal organogenesis but acts as a teratogen at high levels during embryonic and fetal development. Retinoic acid functions through its interaction with the nuclear protein, retinoic acid receptor (RAR). RAR belongs to the steroid and thyroid hormone superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. RAR exists as three major subtypes: alpha, beta and gamma. Two main isoforms of RAR gamma exist: RAR gamma-1 has been found to be predominantly expressed in skin, while RAR gamma-2 has been found early in embryogenesis and in embryonal carcinoma cells. RAR gamma is also known as RARD. The corresponding gene for the retinoic acid receptor gamma 1 is NR1B3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nuclear receptor subfamily 1 group B member 3; RAR Gamma-1; RAR-gamma; retinoic acid; retinoic acid nuclear receptor gamma variant 1; retinoic acid nuclear receptor gamma variant 2; retinoic acid receptor; Retinoic acid receptor gamma; retinoic acid receptor, gamma
Gene Aliases: NR1B3; RARC; RARG
UniProt ID: (Human) P13631
Entrez Gene ID: (Human) 5916
Molecular Function:
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
neural tube closure
glandular epithelial cell development
retinal pigment epithelium development
growth plate cartilage chondrocyte growth
transcription initiation from RNA polymerase II promoter
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of cell size
anterior/posterior pattern specification
embryonic camera-type eye development
regulation of myelination
negative regulation of chondrocyte differentiation
response to retinoic acid
embryonic hindlimb morphogenesis
multicellular organism growth
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of programmed cell death
steroid hormone mediated signaling pathway
regulation of myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
embryonic eye morphogenesis
retinoic acid receptor signaling pathway
canonical Wnt signaling pathway
face development
trachea cartilage development
prostate gland epithelium morphogenesis
Harderian gland development
cellular response to retinoic acid
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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