This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed.
Protein Aliases: latexin-like; PERG-1; Phorbol ester-induced gene 1 protein; RAR-responsive protein TIG1; retinoic acid receptor responder (tazarotene induced) 1; Retinoic acid receptor responder protein 1; Tazarotene-induced gene 1 protein
Gene Aliases: LXNL; PEIG1; PERG-1; RARRES1; TIG1
UniProt ID: (Human) P49788
Entrez Gene ID: (Human) 5918
Molecular Function: protease inhibitor