RB-like 1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and RB-like 1 can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that RB-like 1 may also be a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 107 kDa retinoblastoma-associated protein; MGC40006; p107; pRb1; retinoblastoma-like 1; Retinoblastoma-like protein 1
Gene Aliases: CP107; p107; PRB1; RBL1
UniProt ID: (Human) P28749
Entrez Gene ID: (Human) 5933
Molecular Function: chromatin/chromatin-binding, or -regulatory protein