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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1-5 µg/mL | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
3 µg/mL | - |
ELISA (ELISA) |
10 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG2a, kappa |
Class |
Monoclonal |
Type |
Antibody |
Clone |
2B6 |
Immunogen |
RBM5 (AAH02957, 75 a.a. approximately 184 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
See Label |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4 |
Contains |
no preservative |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Sequence of this protein is as follows: GYHSDGDYGE HDYRHDISDE RESKTIMLRG LPITITESDI REMMESFEGP QPADVRLMKR KTGVSRGFAF VEFYHLQDAT SWMEANQKKL VIQGKHIAMH YSNPRPKFED
DEF-3 and LUCA15 belong to an evolutionarily conserved family of RNA binding proteins and share similar expression patterns. Both DEF-3 and LUCA15 are highly expressed in adult heart and thymus as well as fetal kidney. Conversely, fetal thymus and adult kidney express very little DEF-3 and LUCA15. In the haemopoietic system of mice, the expression of DEF-3 is downregulated upon differentiation of progenitor cells into granulocytes but persists during macrophage development. Both DEF-3 and LUCA15 contain two zinc finger motifs, a bipartite nuclear signal and two RNA binding motifs. DEF-3 and LUCA15 are capable of specifically binding poly(G) RNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Protein G15; Putative tumor suppressor LUCA15; Renal carcinoma antigen NY-REN-9; RNA-binding motif protein 5; RNA-binding protein 5
Gene Aliases: G15; H37; LUCA15; RBM5; RMB5
UniProt ID: (Human) P52756
Entrez Gene ID: (Human) 10181
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