Peptide Sequence: KAEELHYPLG ERRSDYDREA LLGVQEDVDE YVKLGHEEQQ KRLQAIIKKI DLDSDGFLTE SELSSWIQMS FKHYAMQEAK QQFVEYDKNS DDTVTWDEYN IQMYDRVIDF DENTALDDAE EESFRKLHLK DKKRFEKANQ DSGPGLSLEE FIAFEHPEEV DYMTEFVIQE ALEEHDKNGD GFVSLEEFLG DYRWDPTANE DPEWILVEKD RFVNDYDKDN DGRLDPQELL PWVVPNNQGI AQEEALHLID EMDLNGDKKL SEEEILENPD LFLTSEATDY GRQLHDDYFY HDEL
Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
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Protein Aliases: Calcipressin-2; Down syndrome candidate region 1-like 1; Down syndrome critical region gene 1-like 1; MCIP2; Myocyte-enriched calcineurin-interacting protein 2; Regulator of calcineurin 2; thyroid hormone-responsive (skin fibroblasts); Thyroid hormone-responsive protein ZAKI-4
Gene Aliases: CSP2; DSCR1L1; MCIP2; RCAN2; RCN2; ZAKI-4; ZAKI4
UniProt ID: (Human) Q14206
Entrez Gene ID: (Human) 10231
Molecular Function: intercellular signal molecule