The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 38 kD subunit. This subunit is essential for the interaction between the 140 kD subunit and the core complex that consists of the 36, 37, and 40 kD subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Protein Aliases: A1 38 kDa subunit; Activator 1 38 kDa subunit; Activator 1 subunit 3; DNA-binding; MGC5276; Polymorphism; replication factor C (activator 1) 3, 38kDa; Replication factor C 38 kDa subunit; Replication factor C subunit 3; RF-C 38 kDa subunit; RFC, 38 kD subunit
Gene Aliases: RFC3; RFC38
UniProt ID: (Human) P40938
Entrez Gene ID: (Human) 5983
Molecular Function: DNA-directed DNA polymerase