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|Tested species reactivity||Many|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Purified wheat germ RNA polymerase II.|
|Storage buffer||PBS, pH 7.4|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-10 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|ChIP assay (ChIP)||See 1 publications below|
MA1-10882 detects RNA Polymerase II from eukaryotic samples.
MA1-10882 has been successfully used in Western blot applications.
The MA1-10882 immunogen is purified wheat germ RNA polymerase II.
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
S100A14: novel modulator of terminal differentiation in esophageal cancer.
MA1-10882 was used in ChIP assay to study the role of S100A14 in esophageal cancer terminal differentiation
|Chen H,Ma J,Sunkel B,Luo A,Ding F,Li Y,He H,Zhang S,Xu C,Jin Q,Wang Q,Liu Z||Molecular cancer research : MCR (11:1542)||2013|
DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase II subunit RPB1; DNA-directed RNA polymerase III largest subunit; polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; polymerase (RNA) II subunit A; RNA POL2; RNA polymerase II 1; RNA polymerase II subunit B1; RNA-directed RNA polymerase II subunit RPB1
220kDa; hRPB220; hsRPB1; POLR2; POLR2A; POLRA; RPB1; RPBh1; Rpii215; RpIILS; RPO2; Rpo2-1; RPOL2