The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.
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Protein Aliases: E3 ubiquitin ligase RNF4; E3 ubiquitin-protein ligase RNF4; Protein SNURF; RING finger protein 4; RING-type E3 ubiquitin transferase RNF4; RNF4; Small nuclear ring finger protein; SNURF
Gene Aliases: AU018689; Gtrgeo8; RES4-26; RNF4; SLX5; SNURF
Molecular Function: ubiquitin-protein ligase