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|Tested species reactivity||Human , Mouse|
|Published species reactivity||Virus , Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||specific to Human ROC1C|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 2 publications below|
ROC1 and ROC2 are the two highly conserved RING finger proteins that are homologous to APC11, a subunit of the anaphase-promoting complex (APC). ROC1 and ROC2 commonly interact with all cullins while APC11 specifically interacts with APC2, a cullin-related APC subunit. ROC1 and APC11 immunocomplexes can catalyze isopeptide ligations to form polyubiquitin chains in an E1- and E2-dependent manner. ROC1 is thought to play a unique role in the ubiquitination reaction by heterodimerizing with cullin1 to catalyze ubiquitin polymerization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.
||Emberley ED,Mosadeghi R,Deshaies RJ||The Journal of biological chemistry (287:29679)||2012|
Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain.
||Ulane CM,Kentsis A,Cruz CD,Parisien JP,Schneider KL,Horvath CM||Journal of virology (79:10180)||2005|
BA554C12.1; E3 ubiquitin-protein ligase RBX1; regulator of cullins 1; RING box protein 1; RING finger protein 75; ring-box 1, E3 ubiquitin protein ligase; RING-box protein 1; RNF75; ROC1; ZYP protein
1500002P15Rik; AA517855; BA554C12.1; RBX1; RNF75; ROC1