MA5-17165 targets ROCK1 in pep-ELISA and WB applications and shows reactivity with Human samples.
The MA5-17165 immunogen is purified recombinant fragment of human ROCK1 expressed in E. Coli.
MA5-17165 detects ROCK1 which has a predicted molecular weight of approximately 158kDa.
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: p160 ROCK-1; p160ROCK; Renal carcinoma antigen NY-REN-35; Rho-associated protein kinase 1; Rho-associated, coiled-coil containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK-I
Gene Aliases: P160ROCK; ROCK-I; ROCK1
UniProt ID: (Human) Q13464
Entrez Gene ID: (Human) 6093