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Product Details
MA5-36016
| Applications | Tested Dilution | Publications |
|---|---|---|
Flow Cytometry (Flow) |
1:25-1:100 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG2b |
Class |
Monoclonal |
Type |
Antibody |
Clone |
03 |
Immunogen |
Recombinant Human CD136/MST1R Protein |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS |
Contains |
no preservative |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2866628 |
Target Information
Macrophage-stimulatin 1 receptor (MST1R/Ron), a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. MST1R/Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uteru.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-met-related tyrosine kinase; CD136; CDw136; Macrophage-stimulating protein receptor; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain; MSP receptor; MST1R variant RON30; MST1R variant RON62; p185-Ron; Protein-tyrosine kinase 8; PTK8 protein tyrosine kinase 8; RON variant E2E3
Gene Aliases: CD136; CDw136; MST1R; PTK8; RON
UniProt ID: (Human) Q04912
Entrez Gene ID: (Human) 4486
Molecular Function:
transmembrane signal receptor
movement of cell or subcellular component
defense response
signal transduction
single fertilization
positive regulation of cell proliferation
response to virus
peptidyl-tyrosine phosphorylation
macrophage colony-stimulating factor signaling pathway
positive regulation of MAP kinase activity
innate immune response
hepatocyte growth factor receptor signaling pathway
positive regulation of protein kinase B signaling
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