Product References
Gallic Acid Ameliorates Atopic Dermatitis-Like Skin Inflammation Through Immune Regulation in a Mouse Model.
Clinical, cosmetic and investigational dermatology
Hu G,Zhou X
14-6981-82 was used in Western Blot to show that GA could ameliorate AD-like skin inflammation possibly through Th17 mediated immune regulation in a DNCB-induced mouse model.
Thu Apr 28 00:00:00 EDT 2022
Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice.
Molecular brain
Kim J,Suh YH,Chang KA
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6981-82) in Western Blot
Wed Jan 13 00:00:00 EST 2021
Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death.
Nature communications
Hayashi K,Nikolos F,Lee YC,Jain A,Tsouko E,Gao H,Kasabyan A,Leung HE,Osipov A,Jung SY,Kurtova AV,Chan KS
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6981-82) in Flow Cytometry
Mon Dec 07 00:00:00 EST 2020
IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis.
ImmunoHorizons
Poholek CH,Dulson SJ,Zajac AJ,Harrington LE
14-6981 was used in Flow cytometry/Cell sorting to reveal a novel role for IL-21 in shaping innate lymphoid cell responses in the intestine and provide one mechanism by which effector CD4 T cells can influence innate immunity.
Tue Jun 04 00:00:00 EDT 2019
BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues.
PLoS pathogens
Arnold IC,Zhang X,Artola-Boran M,Fallegger A,Sander P,Johansen P,Müller A
14-6981 was used in Flow cytometry/Cell sorting to study the role of BATF3-dependent DCs in the recruitment of CXCR3+ effector and regulatory T-cells to target tissues and in their local expansion.
Sat Jun 01 00:00:00 EDT 2019
Interleukin-17A blockade reduces albuminuria and kidney injury in an accelerated model of diabetic nephropathy.
Kidney international
Lavoz C,Matus YS,Orejudo M,Carpio JD,Droguett A,Egido J,Mezzano S,Ruiz-Ortega M
14-6981 was used in Western Blotting to study the role of IL-17A on experimental diabetic neuropathy pathogenesis.
Sat Jun 01 00:00:00 EDT 2019
Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.
The Journal of experimental medicine
Melo-Gonzalez F,Kammoun H,Evren E,Dutton EE,Papadopoulou M,Bradford BM,Tanes C,Fardus-Reid F,Swann JR,Bittinger K,Mabbott NA,Vallance BA,Willinger T,Withers DR,Hepworth MR
14-6981-82 was used in Flow Cytometry to study the mechanisms that modulate the magnitude and quality of T cell-dependent IgA responses.
Mon Apr 01 00:00:00 EDT 2019
Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.
The Journal of clinical investigation
Mande P,Zirak B,Ko WC,Taravati K,Bride KL,Brodeur TY,Deng A,Dresser K,Jiang Z,Ettinger R,Fitzgerald KA,Rosenblum MD,Harris JE,Marshak-Rothstein A
14-6981 was used in Flow cytometry/Cell sorting to provide a relevant system for exploring the pathophysiology of cutaneous lupus erythematosus (CLE) as well as the negative regulatory role of TLR9.
Mon Jul 02 00:00:00 EDT 2018
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6981-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
IL-1β and IL-23 Promote Extrathymic Commitment of CD27+CD122- γδ T Cells to γδT17 Cells.
Journal of immunology (Baltimore, Md. : 1950)
Muschaweckh A,Petermann F,Korn T
14-6981 was used in Immunocytochemistry to study the mechanisms by which the peripheral pool of γδ T cells retain a considerable degree of plasticity.
Sun Oct 15 00:00:00 EDT 2017
miR-451 limits CD4+ T cell proliferative responses to infection in mice.
Immunologic research
Chapman LM,Ture SK,Field DJ,Morrell CN
14-6981-82 was used in Flow Cytometry to demonstrate that miR-451 is a regulator of host immune responses to Plasmodium infection, particularly in the control of CD4+ T cell proliferation via a Myc-dependent pathway.
Tue Aug 01 00:00:00 EDT 2017
Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor.
eLife
Redhu NS,Bakthavatchalu V,Conaway EA,Shouval DS,Tsou A,Goettel JA,Biswas A,Wang C,Field M,Muller W,Bleich A,Li N,Gerber GK,Bry L,Fox JG,Snapper SB,Horwitz BH
14-6981-82 was used in Flow Cytometry to show that IL10R-mediated regulation of macrophage function during the early postnatal period is essential to prevent murine colitis.
Wed Jul 05 00:00:00 EDT 2017
Upregulation of SOCS3 in lung CD4+ T cells in a mouse model of chronic PA lung infection and suppression of Th17‑mediated neutrophil recruitment in exogenous SOCS3 transfer in vitro.
Molecular medicine reports
Ding FM,Liao RM,Chen YQ,Xie GG,Zhang PY,Shao P,Zhang M
14-6981 was used in Western Blotting to investigate the activation of the STAT3/Th17 signal pathway and the expression of SOCS3 in the lung CD4+ T cells in a mouse model of chronic PA lung infection.
Sat Jul 01 00:00:00 EDT 2017
Upregulation of SOCS3 in lung CD4+ T cells in a mouse model of chronic PA lung infection and suppression of Th17‑mediated neutrophil recruitment in exogenous SOCS3 transfer in vitro.
Molecular medicine reports
Ding FM,Liao RM,Chen YQ,Xie GG,Zhang PY,Shao P,Zhang M
14-6981 was used in Western Blotting to investigate the activation of the STAT3/Th17 signal pathway and the expression of SOCS3 in the lung CD4+ T cells in a mouse model of chronic PA lung infection.
Sat Jul 01 00:00:00 EDT 2017
Stability and function of regulatory T cells expressing the transcription factor T-bet.
Nature
Levine AG,Mendoza A,Hemmers S,Moltedo B,Niec RE,Schizas M,Hoyos BE,Putintseva EV,Chaudhry A,Dikiy S,Fujisawa S,Chudakov DM,Treuting PM,Rudensky AY
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6981-82) in Flow Cytometry
Thu Jun 15 00:00:00 EDT 2017
Administration of RANKL boosts thymic regeneration upon bone marrow transplantation.
EMBO molecular medicine
Lopes N,Vachon H,Marie J,Irla M
14-6981-82 was used in Flow Cytometry to indicate that RANKL may be clinically useful to improve T-cell function recovery after bone marrow transplantation by controlling multiple facets of thymic regeneration.
Thu Jun 01 00:00:00 EDT 2017
Armc5 deletion causes developmental defects and compromises T-cell immune responses.
Nature communications
Hu Y,Lao L,Mao J,Jin W,Luo H,Charpentier T,Qi S,Peng J,Hu B,Marcinkiewicz MM,Lamarre A,Wu J
14-6981 was used in Flow cytometry/Cell sorting to study the developmental defects caused by ARMC5 deletion and how T-cell immune responses are compromised.
Tue Feb 07 00:00:00 EST 2017
Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.
Cell
Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M
14-6981-82 was used in Mass cytometry to demonstrate a novel mutualistic host-protozoan interaction that increases mucosal host defenses at the cost of an increased risk of inflammatory disease.
Thu Oct 06 00:00:00 EDT 2016
FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy.
The Journal of clinical investigation
Lexmond WS,Goettel JA,Lyons JJ,Jacobse J,Deken MM,Lawrence MG,DiMaggio TH,Kotlarz D,Garabedian E,Sackstein P,Nelson CC,Jones N,Stone KD,Candotti F,Rings EH,Thrasher AJ,Milner JD,Snapper SB,Fiebiger E
14-6981 was used in Flow cytometry/Cell sorting to investigate the mechanism by which FOXP3+ T regulatory cells and WASP protein together restrain Th-2 mediated food allergy.
Mon Oct 03 00:00:00 EDT 2016
Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression.
Nature communications
Chou TF,Chuang YT,Hsieh WC,Chang PY,Liu HY,Mo ST,Hsu TS,Miaw SC,Chen RH,Kimchi A,Lai MZ
14-6981 was used in Western Blotting to study tumour suppressor death-associated protein kinases as treatments for Th17-associated inflammatory diseases.
Fri Jun 17 00:00:00 EDT 2016
Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity.
Nature immunology
Xing S,Li F,Zeng Z,Zhao Y,Yu S,Shan Q,Li Y,Phillips FC,Maina PK,Qi HH,Liu C,Zhu J,Pope RM,Musselman CA,Zeng C,Peng W,Xue HH
14-6981 was used in Flow cytometry/Cell sorting to reveal that sequence-specific transcription factors can utilise intrinsic HDAC activity to guard cell identity by repressing lineage-inappropriate genes.
Wed Jun 01 00:00:00 EDT 2016
FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration.
PloS one
Castiglioni A,Corna G,Rigamonti E,Basso V,Vezzoli M,Monno A,Almada AE,Mondino A,Wagers AJ,Manfredi AA,Rovere-Querini P
14-6981 was used in Western Blotting to demonstrate that regulatory T-cells are critical in effective skeletal muscle regeneration.
Sun May 01 00:00:00 EDT 2016
5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation.
Oncotarget
Wang J,Peng L,Zhang R,Zheng Z,Chen C,Cheung KL,Cui M,Bian G,Xu F,Chiang D,Hu Y,Chen Y,Lu G,Yang J,Zhang H,Yang J,Zhu H,Chen SH,Liu K,Zhou MM,Sikora AG,Li L,Jiang B,Xiong H
14-6981 was used in Western Blotting to investigate the function of 5-Fluorouracil in the modulation of immune cells.
Tue Apr 12 00:00:00 EDT 2016
Differential Responsiveness of Innate-like IL-17- and IFN-γ-Producing γδ T Cells to Homeostatic Cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Corpuz TM,Stolp J,Kim HO,Pinget GV,Gray DH,Cho JH,Sprent J,Webster KE
14-6981-82 was used in Flow Cytometry to suggest that γδ T cell subsets do not directly compete with each other for cytokines, but instead fall into resource niches with other functionally similar lymphocytes.
Fri Jan 15 00:00:00 EST 2016
A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans.
PloS one
Dong B,Li D,Li R,Chen SC,Liu W,Liu W,Chen L,Chen Y,Zhang X,Tong Z,Xia Y,Xia P,Wang Y,Duan Y
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6981-82) in Western Blot
Mon Sep 28 00:00:00 EDT 2015
A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans.
PloS one
Dong B,Li D,Li R,Chen SC,Liu W,Liu W,Chen L,Chen Y,Zhang X,Tong Z,Xia Y,Xia P,Wang Y,Duan Y
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6981-82) in Western Blot
Mon Sep 28 00:00:00 EDT 2015
Tertiary Lymphoid Structures in Rheumatoid Arthritis: NF-κB-Inducing Kinase-Positive Endothelial Cells as Central Players.
The American journal of pathology
Noort AR,van Zoest KP,van Baarsen LG,Maracle CX,Helder B,Papazian N,Romera-Hernandez M,Tak PP,Cupedo T,Tas SW
14-6981 was used in Immunofluorescence on frozen tissues to investigate the relation between NIK(+) endothelial cells, precursor follicular dendritic cells, and group 3 innate lymphoid cells.
Wed Jul 01 00:00:00 EDT 2015
Leptin receptor signaling in T cells is required for Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Reis BS,Lee K,Fanok MH,Mascaraque C,Amoury M,Cohn LB,Rogoz A,Dallner OS,Moraes-Vieira PM,Domingos AI,Mucida D
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6981-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2015
Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting.
Nature biotechnology
Chen HJ,Sun J,Huang Z,Hou H,Arcilla M,Rakhilin N,Joe DJ,Choi J,Gadamsetty P,Milsom J,Nandakumar G,Longman R,Zhou XK,Edwards R,Chen J,Chen KY,Bu P,Wang L,Xu Y,Munroe R,Abratte C,Miller AD,Gümüş ZH,Shuler M,Nishimura N,Edelmann W,Shen X,Lipkin SM
14-6981 was used in Flow cytometry/Cell sorting to create chemokine-targeted mouse models that recapitulate the majority of common human somatic CRC mutations.
Mon Jun 01 00:00:00 EDT 2015
SIRT1 deacetylates RORγt and enhances Th17 cell generation.
The Journal of experimental medicine
Lim HW,Kang SG,Ryu JK,Schilling B,Fei M,Lee IS,Kehasse A,Shirakawa K,Yokoyama M,Schnölzer M,Kasler HG,Kwon HS,Gibson BW,Sato H,Akassoglou K,Xiao C,Littman DR,Ott M,Verdin E
14-6981 was used in Western Blotting to report that Sirtuin 1, a protein deacetylase, promotes autoimmunity by deacetylating RORγt, the signature transcription factor of T helper 17 cells.
Mon May 04 00:00:00 EDT 2015
Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine.
Nature immunology
Bando JK,Liang HE,Locksley RM
14-6981 was used in Immunohistochemistry to identify extrahepatic arginase-1(+) Id2(+) fetal innate lymphoid cell (ILC) precursors that express a transitional developmental phenotype and differentiate into ILC1s, ILC2s and ILC3s in vitro.
Sun Feb 01 00:00:00 EST 2015
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue.
Nature immunology
Lynch L,Michelet X,Zhang S,Brennan PJ,Moseman A,Lester C,Besra G,Vomhof-Dekrey EE,Tighe M,Koay HF,Godfrey DI,Leadbetter EA,Sant'Angelo DB,von Andrian U,Brenner MB
14-6981 was used in Flow cytometry/Cell sorting to report a unique transcriptional program of iNKT cells in adipose tissue, making them unique regulators of immunological homeostasis.
Thu Jan 01 00:00:00 EST 2015
Cutting edge: Failure of antigen-specific CD4+ T cell recruitment to the kidney during systemic candidiasis.
Journal of immunology (Baltimore, Md. : 1950)
Drummond RA,Wallace C,Reid DM,Way SS,Kaplan DH,Brown GD
14-6981 was used in Flow cytometry/Cell sorting to explain the redundancy of CD4(+) T cells for defense against systemic infection with Candida albicans by characterising C. albicans-specific T cells.
Mon Dec 01 00:00:00 EST 2014
Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice.
PloS one
Samuelson EM,Laird RM,Papillion AM,Tatum AH,Princiotta MF,Hayes SM
14-6981 was used in Flow cytometry/Cell sorting to demonstrate how BLK risk alleles confer susceptibility to systemic lupus erythematosus.
Tue Nov 11 00:00:00 EST 2014
CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.
eLife
Linterman MA,Denton AE,Divekar DP,Zvetkova I,Kane L,Ferreira C,Veldhoen M,Clare S,Dougan G,Espéli M,Smith KG
14-6981 was used in Flow cytometry/Cell sorting to determine the role for CD28 after T cell priming.
Mon Oct 27 00:00:00 EDT 2014
IL-17A is a novel player in dialysis-induced peritoneal damage.
Kidney international
Rodrigues-Díez R,Aroeira LS,Orejudo M,Bajo MA,Heffernan JJ,Rodrigues-Díez RR,Rayego-Mateos S,Ortiz A,Gonzalez-Mateo G,López-Cabrera M,Selgas R,Egido J,Ruiz-Ortega M
14-6981 was used in Western Blotting to identify IL-17A as a key mediator of peritoneal inflammation and fibrosis in dialysis patients.
Fri Aug 01 00:00:00 EDT 2014
IL-17A is a novel player in dialysis-induced peritoneal damage.
Kidney international
Rodrigues-Díez R,Aroeira LS,Orejudo M,Bajo MA,Heffernan JJ,Rodrigues-Díez RR,Rayego-Mateos S,Ortiz A,Gonzalez-Mateo G,López-Cabrera M,Selgas R,Egido J,Ruiz-Ortega M
14-6981 was used in Western Blotting to identify IL-17A as a key mediator of peritoneal inflammation and fibrosis in dialysis patients.
Fri Aug 01 00:00:00 EDT 2014
CD5 enhances Th17-cell differentiation by regulating IFN-γ response and RORγt localization.
European journal of immunology
McGuire DJ,Rowse AL,Li H,Peng BJ,Sestero CM,Cashman KS,De Sarno P,Raman C
14-6981 was used in Flow cytometry/Cell sorting to investigate a novel mechanism for the modulation of the generation of Th17 cells.
Tue Apr 01 00:00:00 EDT 2014
Islet antigen-specific Th17 cells can induce TNF-α-dependent autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Li CR,Mueller EE,Bradley LM
14-6981 was used in Flow cytometry/Cell sorting to identify a previously unknown mechanism by which Th17 cells can contribute to T1D.
Sat Feb 15 00:00:00 EST 2014
Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity.
Nature medicine
Kim HY,Lee HJ,Chang YJ,Pichavant M,Shore SA,Fitzgerald KA,Iwakura Y,Israel E,Bolger K,Faul J,DeKruyff RH,Umetsu DT
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6981-82) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2014
Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses.
World journal of gastroenterology
Chen QQ,Yan L,Wang CZ,Wang WH,Shi H,Su BB,Zeng QH,Du HT,Wan J
Wed Aug 07 00:00:00 EDT 2013
The C-terminal module IV of connective tissue growth factor is a novel immune modulator of the Th17 response.
Laboratory investigation; a journal of technical methods and pathology
Rodrigues-Díez R,Rodrigues-Díez RR,Rayego-Mateos S,Suarez-Alvarez B,Lavoz C,Stark Aroeira L,Sánchez-López E,Orejudo M,Alique M,Lopez-Larrea C,Ortiz A,Egido J,Ruiz-Ortega M
14-6981 was used in Western Blotting to reveal that CCN2's C-terminal module induces Th17 differentiation of human Th17 cells and causes a renal Th17 inflammatory response.
Mon Jul 01 00:00:00 EDT 2013
T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation.
The Journal of experimental medicine
Zhang R,Lu G,Shen Y,Peng L,Zhu C,Cui M,Wang W,Arnaboldi P,Tang M,Gupta M,Qi CF,Jayaraman P,Zhu H,Jiang B,Chen SH,He JC,Ting AT,Zhou MM,Kuchroo VK,Morse HC,Ozato K,Sikora AG,Xiong H
14-6981 was used in Western Blotting to study the effect of inducible nitric oxide synthase on T(H)17 cell differentiation.
Mon Jul 01 00:00:00 EDT 2013
T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation.
The Journal of experimental medicine
Zhang R,Lu G,Shen Y,Peng L,Zhu C,Cui M,Wang W,Arnaboldi P,Tang M,Gupta M,Qi CF,Jayaraman P,Zhu H,Jiang B,Chen SH,He JC,Ting AT,Zhou MM,Kuchroo VK,Morse HC,Ozato K,Sikora AG,Xiong H
14-6981 was used in Western Blotting to study the effect of inducible nitric oxide synthase on T(H)17 cell differentiation.
Mon Jul 01 00:00:00 EDT 2013
T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation.
The Journal of experimental medicine
Zhang R,Lu G,Shen Y,Peng L,Zhu C,Cui M,Wang W,Arnaboldi P,Tang M,Gupta M,Qi CF,Jayaraman P,Zhu H,Jiang B,Chen SH,He JC,Ting AT,Zhou MM,Kuchroo VK,Morse HC,Ozato K,Sikora AG,Xiong H
14-6981 was used in Western Blotting to study the effect of inducible nitric oxide synthase on T(H)17 cell differentiation.
Mon Jul 01 00:00:00 EDT 2013
Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation.
The Journal of experimental medicine
Mielke LA,Jones SA,Raverdeau M,Higgs R,Stefanska A,Groom JR,Misiak A,Dungan LS,Sutton CE,Streubel G,Bracken AP,Mills KH
14-6981 was used in Flow cytometry/Cell sorting to provide novel insights into the molecular events controlling IL-22 transcription.
Mon Jun 03 00:00:00 EDT 2013
Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter.
Journal of autoimmunity
Hermann-Kleiter N,Meisel M,Fresser F,Thuille N,Müller M,Roth L,Katopodis A,Baier G
Sat Dec 01 00:00:00 EST 2012
Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter.
Journal of autoimmunity
Hermann-Kleiter N,Meisel M,Fresser F,Thuille N,Müller M,Roth L,Katopodis A,Baier G
Sat Dec 01 00:00:00 EST 2012
Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter.
Journal of autoimmunity
Hermann-Kleiter N,Meisel M,Fresser F,Thuille N,Müller M,Roth L,Katopodis A,Baier G
Sat Dec 01 00:00:00 EST 2012
Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-β is mediated by suppression of eomesodermin.
Immunity
Ichiyama K,Sekiya T,Inoue N,Tamiya T,Kashiwagi I,Kimura A,Morita R,Muto G,Shichita T,Takahashi R,Yoshimura A
14-6981 was used in Western Blotting to investigate the molecular mechanisms by which TGF-beta allows Th17 cell differentiation via Smad-independent mechanisms, showing that Eomesodermin is suppressed by TGF-beta via the JNK pathway allowing differentiation.
Fri May 27 00:00:00 EDT 2011
Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-β is mediated by suppression of eomesodermin.
Immunity
Ichiyama K,Sekiya T,Inoue N,Tamiya T,Kashiwagi I,Kimura A,Morita R,Muto G,Shichita T,Takahashi R,Yoshimura A
14-6981 was used in Western Blotting to investigate the molecular mechanisms by which TGF-beta allows Th17 cell differentiation via Smad-independent mechanisms, showing that Eomesodermin is suppressed by TGF-beta via the JNK pathway allowing differentiation.
Fri May 27 00:00:00 EDT 2011
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt.
Nature immunology
Lazarevic V,Chen X,Shim JH,Hwang ES,Jang E,Bolm AN,Oukka M,Kuchroo VK,Glimcher LH
14-6981 was used in Western Blotting to identify the factors that negatively regulate the differentiation of overactive interleukin 17-producing helper T cells.
Sat Jan 01 00:00:00 EST 2011
Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation.
Journal of immunology (Baltimore, Md. : 1950)
Pierau M,Engelmann S,Reinhold D,Lapp T,Schraven B,Bommhardt UH
14-6981 was used in Western Blotting to indicate an important role of PKB signals on control of TGF-beta1-mediated T cell responses and, thereby, on tolerizing and inflammatory immune processes.
Sun Nov 15 00:00:00 EST 2009
RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells.
Nature immunology
Sanos SL,Bui VL,Mortha A,Oberle K,Heners C,Johner C,Diefenbach A
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6981-82) in Immunohistochemistry (Frozen)
Thu Jan 01 00:00:00 EST 2009
RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells.
Nature immunology
Sanos SL,Bui VL,Mortha A,Oberle K,Heners C,Johner C,Diefenbach A
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6981-82) in Immunohistochemistry (Frozen)
Thu Jan 01 00:00:00 EST 2009
-WB-20170216130641.jpg?time=20220826?time=20220826 "ROR gamma (t) Antibody (14-6981-82) in WB")
C4 zinc finger nuclear receptor
