|Flow Cytometry (Flow)||2 ug/ml|
|Functional Assay (FN)||Assay Dependent|
|Immunoprecipitation (IP)||Assay dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human tonsillar B cells|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage conditions||4° C, do not freeze|
CD180, also known as RP105 (or Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1 , and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD180; CD180 antigen; LY64; Ly78; Lymphocyte antigen 64; lymphocyte antigen-64 radioprotective; lymphocyte antigen-64, radioprotective, 105kDa; Radioprotective 105 kDa protein
Gene Aliases: CD180; LY64; Ly78; RP105
UniProt ID: (Human) Q99467
Entrez Gene ID: (Human) 4064
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