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|Tested species reactivity||Human, Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 369 and 616 of RPA70 (Uniprot ID#P27694)|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Contains||0.025% ProClin 300|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunocytochemistry (ICC)||See 1 publications below|
PA5-21976 targets RPA 70 kDa subunit in ICC, IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-21976 immunogen is a recombinant fragment corresponding to a region within amino acids 369 and 616 of RPA70 (Uniprot ID#P27694).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
PA5-21976 was used in immunocytochemistry to study why HSC function declines with age
|Flach J,Bakker ST,Mohrin M,Conroy PC,Pietras EM,Reynaud D,Alvarez S,Diolaiti ME,Ugarte F,Forsberg EC,Le Beau MM,Stohr BA,Méndez J,Morrison CG,Passegué E||Nature (512:198)||2014|
HSSB; MST075; MSTP075; REPA1; replication factor A protein 1; replication protein A 70 kDa DNA-binding subunit; replication protein A1, 70kDa; RF-A protein 1; RP-A; RP-A p70; RPA70; single-stranded DNA-binding protein
5031405K23Rik; 70kDa; AA589576; AW557552; HSSB; MST075; REPA1; RF-A; RP-A; Rpa; RPA1; RPA70