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Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
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Protein Aliases: Cerebral protein 1; HUCE1; hucep1; Nucleomethylin; Ribosomal RNA-processing protein 8; RRP-8; RRP8 methyltransferase homolog
Gene Aliases: hucep-1; KIAA0409; NML; RRP8
UniProt ID: (Human) O43159
Entrez Gene ID: (Human) 23378