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The Ku autoantigen is a heterodimer of 70kDa (p70) and approximately 80kDa (p80) proteins. The p70/p80 dimer is important for function of a 460kDa DNA-dependent protein kinase that phosphorylates certain transcription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
Protein Aliases: RNA, U3 small nucleolar interacting protein 2; RRP9 homolog; RRP9, small subunit (SSU) processome component, homolog; U3 small nucleolar ribonucleoprotein-associated 55 kDa protein; U3 small nucleolar RNA-interacting protein 2; U3 snoRNP-associated 55 kDa protein; U3 snoRNP-associated 55-kDa protein
Gene Aliases: RNU3IP2; RRP9; U3-55K; U355K
UniProt ID: (Human) O43818
Entrez Gene ID: (Human) 9136