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This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.
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Protein Aliases: FLJ40906; hRspo1; R-spondin homolog; R-spondin-1; Roof plate-specific spondin-1; RP11-566C13.1
Gene Aliases: CRISTIN3; RSPO; RSPO1
UniProt ID: (Human) Q2MKA7
Entrez Gene ID: (Human) 284654
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