Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
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Protein Aliases: Nuclear receptor subfamily 2 group B member 3; Retinoic acid receptor RXR-gamma; retinoid X receptor; Retinoid X receptor gamma; retinoid X receptor, gamma; RXR gamma
Gene Aliases: NR2B3; RXRC; RXRG
Molecular Function: C4 zinc finger nuclear receptor