Sequence of this protein is as follows: SMAAPSLHPS LGPGIGSPGQ LHSPISTLSS PINGMGPPFS VISSPMGPHS MSVPTTPTLG FSTGSPQL
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
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Protein Aliases: Nuclear receptor subfamily 2 group B member 1; Retinoic acid receptor RXR-alpha; retinoid X nuclear receptor alpha; retinoid X receptor; Retinoid X receptor alpha; retinoid X receptor, alpha; rxr alpha
Gene Aliases: NR2B1; RXRA
UniProt ID: (Human) P19793
Entrez Gene ID: (Human) 6256
Molecular Function: C4 zinc finger nuclear receptor