Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
2 µg/mL | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
3-20 µg/mL | - |
Immunocytochemistry (ICC/IF) |
5 µg/mL | - |
ELISA (ELISA) |
0.1 µg/mL | - |
Immunoprecipitation (IP) |
Assay-dependent | - |
ChIP assay (ChIP) |
Assay-dependent | View 1 publication 1 publication |
Gel Shift (GS) |
Assay-dependent | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human |
Host/Isotype |
Mouse / IgG2a |
Class |
Monoclonal |
Type |
Antibody |
Clone |
K8508 |
Immunogen |
Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human RXR--alpha (2-133 aa). |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Ammonium sulfate precipitation |
Storage buffer |
physiological saline |
Contains |
0.1% sodium azide |
Storage conditions |
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C |
RRID |
AB_2532208 |
This antibody specifically recognizes human RXR alpha and cross reacts with mouse and rat RXR alpha. This antibody does not recognize human RXR beta and gamma.
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Nuclear receptor subfamily 2 group B member 1; Retinoic acid receptor RXR-alpha; retinoid X nuclear receptor alpha; retinoid X receptor; Retinoid X receptor alpha; retinoid X receptor, alpha; rxr alpha; RXR alpha 1
Gene Aliases: 9530071D11Rik; NR2B1; RXRA; RXRalpha1
UniProt ID: (Human) P19793, (Mouse) P28700
Entrez Gene ID: (Human) 6256, (Rat) 25271, (Mouse) 20181
Molecular Function:
C4 zinc finger nuclear receptor
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