This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
This antibody specifically recognizes human RXR alpha and cross reacts with mouse and rat RXR alpha. This antibody does not recognize human RXR beta and gamma.
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: NR2B1; Nuclear receptor subfamily 2 group B member 1; Retinoic acid receptor RXR-alpha; retinoid X nuclear receptor alpha; Retinoid X receptor alpha; retinoid X receptor, alpha; RXR alpha 1
Gene Aliases: 9530071D11Rik; NR2B1; RXRA; RXRalpha1