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Huabio
The fundamental structure of IgG contains two identical heavy chains of about 50 kDa and two identical light chains of about 25 kDa, thus tetrameric quaternary structure. Light chain, which is usually same in a natural IgG molecule, includes kappa chain and lambda chain, but kappa or lambda antibody can exist in one body simultaneously. A heavy chain includes Fab- and Fc-Fragments. The most common type of myeloma is IgG kappa. In IgG kappa myeloma, the myeloma cells produce an immunoglobulin made from two IgG heavy chains bound to two kappa light chains. About 15% of patients have light chain myeloma. In this type of myeloma, the myeloma cells secrete only light chain protein and no heavy chains.
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