Positive Control: 293T transfected with Ras mutant G13D
Predicted Reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Xenopus laevis (100%), Dog (100%), Pig (100%), Chicken (100%), Bovine (100%), Guinea pig (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Ras is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. The process of shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in Ras gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GTPase NRas; N-ras protein part 4; neuroblastoma RAS viral (v-ras) oncogene homolog; Transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog
Gene Aliases: ALPS4; CMNS; HRAS1; N-ras; NCMS; NRAS; NRAS1; NS6
UniProt ID: (Human) P01111
Entrez Gene ID: (Human) 4893
Molecular Function: small GTPase