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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 1200 and 1272 of Human Rent2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-28629 targets Rent2 in IF and WB applications and shows reactivity with Human and mouse samples.
The PA5-28629 immunogen is synthetic peptide corresponding to a region within amino acids 1200 and 1272 of Human Rent2.
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
HUPF2; nonsense mediated mRNA decay factor; Nonsense mRNA reducing factor 2; Regulator of nonsense transcripts 2; RENT2; smg-3; smg-3 homolog; smg-3 homolog, nonsense mediated mRNA decay factor; Up-frameshift suppressor 2 homolog; yeast Upf2p homolog
HUPF2; KIAA1408; RENT2; smg-3; UPF2