|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Peptide corresponding to amino acids from N-terminal region of human retinoic acid receptor, beta-isotype. The antigen is identical in both beta-1 and beta-2 isoforms.|
|Storage buffer||HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Retinoids are metabolites of vitamin A (retinal) and are believed to represent important signaling molecules during vertebrate development and tissue differentiation. Two families of retinoid receptors have been identified. Retinoic acid receptors (RARs) include RARalpha, RARBeta and RARgamma, each of which has a high affinity for all-trans retinoic acids and belongs to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. The ligand binding domains of the RARs are highly conserved and RAR isoforms are expressed in distinct patterns throught development and in the mature organism. Members of the retinoid X receptor (RXR) family, RXRalpha, RXRBeta and RXRgamma, are activated by 9-cis-retinoic acid, a stereoand photoisomer of all-trans-RA that is expressed in vivo in both liver and kidney and may represent a widely used hormone.
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