|Tested species reactivity||Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Hinge peptide corresponding to amino acids from human, mouse and rat retinoid X receptor, beta-isotype.|
|Storage buffer||HEPES, pH 7.5, with 100µg/ml BSA, 0.15M NaCl, 50% glycerol|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||Assay Dependent|
Retinoid X receptors (RXRs) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. The RXR subfamily consists of at least three similar genes, RXR alpha, RXR beta and RXR gamma, all of which control transcription of target genes mediated by retinoids. RXR beta controls expression of many genes that respond to hormones and vitamins, including thyroid hormone, estrogen, retinoids and vitamin D. RXR beta, also known as RCoR1, controls a wide array of genes because of its ability to heterodimerize with other hormone receptors including the thyroid hormone receptor (THR), vitamin D receptor (VDR) and retinoic acid receptor (RAR).
The corresponding gene for the retinoid X receptor beta is NR2B2.
DAUDI6; H-2RIIBP; MHC class I promoter binding protein; NR2B2; nuclear receptor co-regulator 1; nuclear receptor coregulator 1; nuclear receptor subfamily 2 group B member 2; RCoR-1; retinoic acid receptor RXR-beta; retinoic acid receptor, beta; retinoid X nuclear receptor beta