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|Tested species reactivity||Rat|
|Published species reactivity||Rat, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Human S/L-MAG fusion protein with a C-terminal region insert.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Upregulation of axon guidance molecules in the adult central nervous system of Nogo-A knockout mice restricts neuronal growth and regeneration.
34-6200 was used in western blot to study the increased levels of certain axon guidance proteins in the CNS of Nogo-A ablated mice and their role in limiting the outgrowth of neurites in the absence of Nogo.
|Kempf A,Montani L,Petrinovic MM,Schroeter A,Weinmann O,Patrignani A,Schwab ME||The European journal of neuroscience (38:3567)||2013|
|Mouse||Not Cited||Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C.||Shin D,Lin ST,Fu YH,Ptácek LJ||Proceedings of the National Academy of Sciences of the United States of America (110:19101)||2013|
|Mouse||Not Cited||Conduction block in PMP22 deficiency.||Bai Y,Zhang X,Katona I,Saporta MA,Shy ME,O'Malley HA,Isom LL,Suter U,Li J||The Journal of neuroscience : the official journal of the Society for Neuroscience (30:600)||2010|
|Rat||1:200||Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain.||Shen S,Li J,Casaccia-Bonnefil P||The Journal of cell biology (169:577)||2005|
brain neuron cytoplasmic protein 3; GMA; myelin-associated glycoprotein; S-MAG; S-MAG (C-term.); sialic acid binding Ig-like lectin 4A; sialic acid-binding Ig-like lectin 4a; sialic acid-binding immunoglobulin-like lectin 4A; SIGLEC-4A; SIGLEC4A