This antibody stains S100 in Schwannomas, ependymomas, astrogliomas, almost all benign and malignant melanomas and their metastases. Immunostaining of formalin-fixed paraffin-embedded tissues require no special pretreatment. Use at a dilution of 1:50-1:100 for 30 minutes at room temperature. A suggested positive control for this product is melanoma.
S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes.
Protein Aliases: Protein S100-A1; Protein S100-B; S 100; S-100 calcium-binding protein, beta chain; S-100 protein alpha chain; S-100 protein beta chain; S-100 protein subunit alpha; S-100 protein subunit beta; S100 alpha; S100 calcium-binding protein A1; S100 calcium-binding protein B; S100 calcium-binding protein beta (neural); S100 calcium-binding protein, beta (neural); S100 protein, alpha polypeptide; S100 protein, beta polypeptide; S100 protein, beta polypeptide, neural; S100alpha
Gene Aliases: AI266795; AI850290; BOS_1447; BOS_2809; Bpb; NEF; S100; S100-alpha; S100-B; S100A; S100A1; S100B; S100beta; S100P