The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known.
Protein Aliases: Protein S100-A7; Psoriasin; psoriasin 1; S100 calcium-binding protein A7; S100 calcium-binding protein A7 (psoriasin 1)
Gene Aliases: PSOR1; S100A7; S100A7C
UniProt ID: (Human) P31151
Entrez Gene ID: (Human) 6278
Molecular Function: calmodulin-related