|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (350 FSRSKSDNSSHPQKDEGDN 368) of S1PR1 protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||4-6 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
S1PR1 (Sphingosine-1-phosphate receptor 1) is also known as Endothelial differentiation G-protein coupled receptor 1 (EDG-1). It is the receptor for, and binds to, the lipid signaling molecule Sphingosine 1-phosphate (S1P) with high affinity and specificity, and is suggested to be involved in regulatory processes of differentiation of endothelial cells and cell-cell adhesion. S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. S1PR1, an inducible epithelial cell G-protein-coupled receptor, may be involved in the processes that regulate the differentiation of endothelial cells. It seems to be coupled to the G (i) subclass of heteromeric G proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.